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We study the non-equilibrium phase transition in a model for epidemic spreading on scale-free networks. The model consists of two particle species and , and the coupling between them is taken to be asymmetric; induces while suppresses . This model describes the spreading of an epidemic on networks equipped with a reactive immune system. We present analytic results on the phase diagram and the critical behavior, which depends on the degree exponent of the underlying scale-free networks. Numerical simulation results that support the analytic results are also presented.

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