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We propose a cyclic refrigeration principle based on mesoscopic electron transport. Synchronous sequential tunnelling of electrons in a Coulomb-blockaded device, a normal metal-superconductor single-electron box, results in a cooling power of at temperature over a wide range of cycle frequencies . Electrostatic work, done by the gate voltage source, removes heat from the Coulomb island with an efficiency of , where is the superconducting gap. The performance is not affected significantly by non-idealities, for instance by offset charges. We propose ways of characterizing the system and of its practical implementation.

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