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Totally asymmetric simple exclusion processes (TASEP) with particles which occupy more than one lattice site and with a local inhomogeneity far away from the boundaries are investigated. These non-equilibrium processes are relevant for the understanding of many biological and chemical phenomena. The steady-state phase diagrams, currents, and bulk densities are calculated using a simple approximate theory and extensive Monte Carlo computer simulations. It is found that the phase diagram for TASEP with a local inhomogeneity is qualitatively similar to homogeneous models, although the phase boundaries are significantly shifted. The complex dynamics is discussed in terms of domain-wall theory for driven lattice systems.

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