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We have fabricated single-Cooper-pair transistors in which the spatial profile of the superconducting gap energy was controlled by oxygen doping. The profile dramatically affects the switching current gate voltage curve of the transistor, changing its period from to . A model based on nonequilibrium quasiparticles in the leads explains our results, including the surprising observation that even devices with a clean period are ``poisoned’’ by small numbers of these quasiparticles.

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