We show that time-correlation functions of arbitrary order for any random
variable in a statistical dynamical system can be calculated as higher-order
response functions of the mean history of the variable. The response is to a
control term'' added as a modification to the master equation for statistical distributions. The proof of the relations is based upon a variational characterization of the generating functional of the time-correlations. The same fluctuation-response relations are preserved within moment-closures for the statistical dynamical system, when these are constructed via the variational Rayleigh-Ritz procedure. For the 2-time correlations of the moment-variables themselves, the fluctuation-response relation is equivalent to an Onsager regression hypothesis’’ for the small fluctuations. For
correlations of higher-order, there is a new effect in addition to such linear
propagation of fluctuations present instantaneously: the dynamical generation
of correlations by nonlinear interaction of fluctuations. In general, we
discuss some physical and mathematical aspects of the {\it Ans"{a}tze}
required for an accurate calculation of the time correlations. We also comment
briefly upon the computational use of these relations, which is well-suited for
automatic differentiation tools. An example will be given of a simple closure
for turbulent energy decay, which illustrates the numerical application of the
relations.

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