We consider a contribution of microlensing to the X-ray variability of high-redshifted QSOs. Cosmologically distributed gravitational microlenses could be localized in galaxies (or even in bulge or halo of gravitational macrolenses) or could be distributed in a uniform way. We have analyzed both cases of such distributions. We found that the optical depth for gravitational microlensing caused by cosmologically distributed deflectors could be significant and could reach at . This means that cosmologically distributed deflectors may contribute significantlly to the X-ray variability of high-redshifted QSOs (). Considering that the upper limit of the optical depth () corresponds to the case where dark matter forms cosmologically distributed deflectors, observations of the X-ray variations of unlensed QSOs can be used for the estimation of the dark matter fraction of microlenses.

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