We consider a contribution of microlensing in X-ray variability of high-redshifted QSOs. Such an effect could be caused by stellar mass objects (SMO) located in a bulge or/and in a halo of this quasar as well as at cosmological distances between an observer and a quasar. Here, we not considerability of microlensing caused by deflectors in our Galaxy since it is well-known from recent MACHO, EROS and OGLE observations that the corresponding optical depth for the Galactic halo and the Galactic bulge is lower than . Cosmologically distributed gravitational microlenses could be localized in galaxies (or even in bulge or halo of gravitational macrolenses) or could be distributed in a uniform way. We have analyzed both cases of such distributions. As a result of our analysis, we obtained that an optical depth for microlensing caused by stellar mass objects is usually small for quasar bulge and quasar halo gravitational microlens distributions ($\tau\sim 10^{-4}$). On the other hand, the optical depth for gravitational microlensing caused by cosmologically distributed deflectors could be significant and could reach at . It means that cosmologically distributed deflectors may significantlly contribute to the X-ray variability of high-redshifted QSOs (). Considering that upper limit of the optical depth () corresponds to the case when dark matter forms cosmologically distributed deflectors, therefore observations of X-ray variations of unlensend QSOs can be used for the estimation of the dark matter fraction of microlenses.

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