As pointed out by Lingenfelter and Ramaty (1977), the shapes of some gamma-ray lines produced by cosmic-ray interactions with the interstellar medium potentially contain valuable information on the physical properties of dust grains, including their compositions and size distributions. The most promising of such lines are at 847, 1369, 1779 and 6129 keV, from 56-Fe*, 24-Mg*, 28-Si* and 16-O*, respectively. We performed detailed calculations of their profiles using, in particular, available laboratory measurements combined with optical model calculations to evaluate the energy distributions of the recoiling excited nuclei. We show that the line shapes are mainly sensitive to relatively large interstellar grains, with radii greater than 0.25 microns. Line fluxes from the inner Galaxy are then predicted.

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