Nuclear medium effects in the neutrino cooling of neutron stars through the exotic reaction channel \gamma \gamma --> \pi^0–> \nu_R \bar{\nu_L} (\nu_L \bar{\nu_R}) are incorporated. Throughout the paper we discuss different possibilities of right-handed neutrinos, massive left-handed neutrinos and standard massless left-handed neutrinos (reaction is then allowed only with medium modified vertices). It is demonstrated that multi-particle effects suppress the rate of this reaction channel by 6-7 orders of magnitude that does not allow to decrease existing experimental upper limit on the corresponding \pi^0\nu\bar{\nu} coupling. Other possibilities of the manifestation of the given reaction channel in differente physical situations, e.g. in the quark color superconducting cores of some neutron stars, are also discussed. We demonstrate that in the color-flavor-locked superconducting phase for temperatures T < (0.1-10) MeV (depending on the effective pion mass and the decay width) the process is feasibly the most efficient neutrino cooling process, although the absolute value of the reaction is rather small.

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