We evaluate the observational constraints on the spectral index , in the context of the CDM hypothesis which represents the simplest viable cosmology. We first take to be practically scale-independent. Ignoring reionization, we find at a nominal 2- level . If we make the more realisitic assumption that reionization occurs when a fraction to 1 of the matter has collapsed, the 2- lower bound is unchanged while the 1- bound rises slightly. These constraints are compared with the prediction of various inflation models. Then we investigate the two-parameter scale-dependent spectral index, predicted by running-mass inflation models, and find that present data allow significant scale-dependence of , which occurs in a physically reasonable regime of parameter space.

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