Based on mapping observations with ASCA, an unusual hot region with a spatial extent of 1 square degree was discovered between M87 and M49 at a center coordinate of R. A. = 12h 27m 36s and Dec. = (J2000). The X-ray emission from the region has a 2-10 keV flux of ergs s cm and a temperature of keV, which is significantly higher than that in the surrounding medium of keV. The internal thermal energy in the hot region is estimated to be $V n k T \sim 10^{60}\sim 10^{-4}^{-3}$. A power-law spectrum with a photon index is also allowed by the data. The hot region suggests there is an energy input due to a shock which is probably caused by the motion of the gas associated with M49, infalling toward the M87 cluster with a velocity km s.

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