We study a Navier-Stokes/Cahn-Hilliard system modeling the evolution of a compressible binary mixture of viscous fluids undergoing phase separation. The novelty of this work is a free energy potential including the physically relevant Flory-Huggins (logarithmic) entropy, as opposed to previous studies in the literature, which only consider regular potentials with polynomial growth. Our main result establishes the existence of global-in-time weak solutions in three-dimensional bounded domains for arbitrarily large initial data. The core contribution is the derivation of new estimates for the chemical potential and the Flory-Huggins entropy arising from a density-dependent Cahn-Hilliard equation under minimal assumptions: non-negative -integrable density with . In addition, we prove that the phase variable, which represents the difference of the mass concentrations, takes value within the physical interval almost everywhere on the set where the density is positive.

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