We study whether the topology underlying a Calabi-Yau manifold can support natural geometric positivity or negativity structures. In even complex dimension (assuming when ), we strengthen a theorem of Oguiso-Peternell by proving that a Calabi-Yau manifold is not homeomorphic to a weak Fano -fold. The same obstruction applies to K"{a}hler manifolds with quasi-positive holomorphic sectional curvature. A transformation-group analogue excludes, in particular, symplectic manifolds admitting Hamiltonian circle actions with isolated fixed points. On the negative side, we show that the fundamental group of a Calabi-Yau manifold is not isomorphic to that of a K"{a}hler hyperbolic manifold. Taken together, these results exhibit a common topological rigidity separating Calabi-Yau manifolds from several fundamental classes governed by geometric positivity or negativity.

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