The biharmonic equation is a prototypical fourth-order partial differential equation whose high-dimensional discretization suffers from rapidly growing degrees of freedom and severe ill-conditioning. We develop QSVT–VTAA quantum linear-system algorithms by constructing explicit block-encodings tailored to periodic, simply supported, and Dirichlet–Neumann boundary conditions. For periodic and simply supported problems, Fourier and sine-transform diagonalizations yield augmented Poisson systems with the condition-number scaling of a second-order operator. For Dirichlet–Neumann problems, we introduce a second-order boundary-corrected finite-difference discretization, establish mesh-independent stability, and construct an explicit block-encoding of the resulting nonsymmetric matrix. We also formulate a coupled-Laplace system with additional boundary unknowns and characterize its complexity in terms of the condition number of the complete augmented matrix. The analysis covers discretization error, block-encoding normalization, gate complexity, and solution extraction under an amplitude-input and quantum-state-output model. Numerical experiments validate the proposed discretizations and the corresponding linear solves.

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