On a complete Riemannian manifold , we study the spectral flow of a family of Callias operators. We derive a codimension zero formula when the dimension of is odd and a codimension one formula when the dimension of is even. These can be seen as analogues of Gromov–Lawson’s relative index theorem and classical Callias index theorem, respectively. Secondly, we introduce an intrinsic definition of K-cowaist on odd-dimensional manifolds, making use of the odd Chern character of a smooth map from the manifold to a unitary group. It behaves just like the usual K-cowaist on even-dimensional manifolds. We then apply the notion of odd K-cowaist and the tool of spectral flow to investigate problems related to positive scalar curvature on spin manifolds. In particular, we prove infinite odd K-cowaist to be an obstruction to the existence of PSC metrics. We obtain quantitative scalar curvature estimates on complete non-compact manifolds and scalar-mean curvature estimates on compact manifolds with boundary. They extend several previous results optimally, which unfolds a major advantage of our method via spectral flow and odd K-cowaist.

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