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In the present paper, we study the Cauchy-Dirichlet problem to the nonlocal nonlinear diffusion equation with polynomial nonlinearities involving time-fractional Caputo derivative and space-fractional -Laplacian operator . We give a simple proof of the comparison principle for the considered problem using purely algebraic relations, for different sets of and . The Galerkin approximation method is used to prove the existence of a local weak solution. The blow-up phenomena, existence of global weak solutions and asymptotic behavior of global solutions are classified using the comparison principle.

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