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We summarize recent developments in the study of hadron-hadron interactions using lattice QCD near the physical pion mass ( MeV), based on the HAL QCD method and its connection to experimental data. In particular, we focus on several key interaction channels shown below. Also, we examine the two-pion exchange (TPE) mechanism, which governs the long-range behavior of interactions between flavor-singlet hadrons, as well as between nucleons and flavor-singlet hadrons.

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