We find and discuss asymptotic formulas for orthonormal polynomials with recurrence coefficients . Our main goal is to consider the case where off-diagonal elements as . Formulas obtained are essentially different for relatively small and large diagonal elements . Our analysis is intimately linked with spectral theory of Jacobi operators with coefficients and a study of the corresponding second order difference equations. We introduce the Jost solutions , , of such equations by a condition for and suggest an Ansatz for them playing the role of the semiclassical Liouville-Green Ansatz for solutions of the Schr"odinger equation. This allows us to study the spectral structure of Jacobi operators and their eigenfunctions by traditional methods of spectral theory developed for differential equations. In particular, we express all coefficients in asymptotic formulas for as in terms of the Wronskian of the solutions and . The formulas obtained for generalize the asymptotic formulas for the classical Hermite polynomials where and .

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