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We develop a method for lattice QCD calculation of the two-photon exchange contribution to the muonic-hydrogen Lamb shift. To demonstrate its feasibility, we present the first lattice calculation with a gauge ensemble at MeV. By adopting the infinite-volume reconstruction method along with an optimized subtraction scheme, we obtain $\Delta E_{} = -28.9(4.9)~\mu + 93.72~\mu/^2 \cdot\langle r_p^2 \rangle\Delta E_{} = 37.4(4.9)~\mu$eV, which is consistent with the previous theoretical results in a range of 20-50 eV.

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