We extend the classical regularity theorem of elliptic operators to maximally hypoelliptic differential operators. More precisely, given vector fields on a smooth manifold which satisfy H"ormander’s bracket generating condition, we define a principal symbol for linear differential operator. Our symbol takes into account the vector fields and their commutators. We show that for an arbitrary differential operator, its principal symbol is invertible if and only if the operator is maximally hypoelliptic. This answers affirmatively a conjecture due to Helffer and Nourrigat. Our result is proven in a more general setting, where we allow each one of the vector fields to have an arbitrary weight. In particular, our theorem generalizes H"ormander’s sum of squares theorem to higher order polynomials.

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