We study the question whether the representations defined by a dense subset of the unit space of a locally compact 'etale groupoid are enough to determine the reduced norm on the groupoid C-algebra. We present sufficient conditions for either conclusion, giving a complete answer when the isotropy groups are torsion-free. As an application we consider the groupoid associated to a left cancellative monoid by Spielberg and formulate a sufficient condition, which we call C-regularity, for the canonical map to be an isomorphism, in which case has a well-defined full semigroup C-algebra . We give two related examples of left cancellative monoids and such that both are not finitely aligned and have non-Hausdorff associated 'etale groupoids, but is C-regular, while is not.

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