In this paper, we investigate the existence of multiple solutions to the following multi-critical elliptic problem \begin{equation}\label{eq:0.1} \left{\begin{aligned} -\Delta u & =\lambda |u|^{p-2}u +\sum_{i=1}^k(|x|^{-(N-\alpha_i)}|u|^{2^_i})|u|^{2^_i-2}u\quad {\rm in}\quad \Omega,\ &u\in H^1_0(\Omega)\ \end{aligned}\right. \end{equation} in connection with the topology of the bounded domain $\Omega\subset ^N, ,N\geq 4\lambda>02^_i=\frac{N+\alpha_i}{N-2}N-4<\alpha_i<N,\ \ i=1,2,\cdot\cdot\cdot, k$ are critical Hardy-Littlewood-Sobolev exponents and with . We show that there is such that if problem \eqref{eq:0.1} possesses at least positive solutions. We also study the existence and uniqueness of solutions for the limit problem of \eqref{eq:0.1}.

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