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Let be a Banach algebra with the properties that and the algebra is commutative. We show that a derivation of maps into ${\rm rad}({\mathcal A})$. Using this, we determine among other things when a generalized derivation of maps into . We also study -centralizing generalized derivations of . Then, for a generalized derivation of we obtain a necessary and sufficient condition for to be still a generalized derivation of . The main applications are concerned with the algebras over locally compact groups. In particular, we deduce these results for bidual of Fourier algebras of discrete amenable groups as an application of our approach.

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