A pair of letters and are said to alternate in a word if, after removing all letters except for the copies of and from , the resulting word is of the form (of even or odd length) or (of even or odd length). A graph is word-representable if there exists a word over the alphabet , such that any two distinct vertices are adjacent in (i.e., ) if and only if the letters and alternate in . A split graph is a graph in which the vertices can be partitioned into a clique and an independent set. Word-representability of split graphs has been studied in a series of papers [2, 5, 7, 9] in the literature. In this work, we give a minimal forbidden induced subgraph characterization of word-representable split graphs with an independent set of size 4, which is an open problem posed by Kitaev and Pyatkin in [9]

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