We consider parametrized systems of generalized polynomial equations (with real exponents) in positive variables, involving monomials with positive parameters; that is, such that with coefficient matrix , exponent matrix , parameter vector (and componentwise product ). Our main result characterizes the existence of a unique, nondegenerate solution (up to an exponential manifold) for all parameters in terms of the relevant geometric objects of the polynomial system: the and the . Technically, we show that unique existence of a nondegenerate solution is equivalent to a composite (monomial-exponential moment) map being a diffeomorphism, and we characterize this property using Hadamard’s global inversion theorem. Additionally, we provide sufficient conditions in terms of sign vectors of the geometric objects, which represent a genuine multivariate generalization of Descartes’ rule of signs for exactly one solution. Finally, we illustrate all objects and results in a concrete example.

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