We study mean curvature flow of -dimensional submanifolds of , the round -sphere of sectional curvature , under the quadratic curvature pinching condition $|A|^{2} < \frac{1}{n-2}|H|^{2} + 4Kn\geq 8|A|^{2} < \frac{4}{3n}|H|^{2}+\frac{n}{2}Kn=7$, and when or . This condition is related to a theorem of Li and Li [Arch. Math., 58:582–594, 1992] which states that the only -dimensional minimal submanifolds of satisfying are the totally geodesic -spheres. We prove the existence of a suitable mean curvature flow with surgeries starting from initial data satisfying the pinching condition. As a result, we conclude that any smoothly, properly immersed submanifold of satisfying the pinching condition is diffeomorphic either to the sphere or to the connected sum of a finite number of handles $S^1\times S^{n-1}n\geq 8$ due to hypersurface counterexamples.

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