Let be a densely defined, closed, symmetric operator in the complex, separable Hilbert space with equal deficiency indices and denote by , , the associated deficiency subspace of . If denotes a self-adjoint extension of in , the Donoghue -operator $M_{A,_i}^{Do} (, \cdot ,)_i(A,_i)$ is given by with the identity operator in , and the orthogonal projection in onto . Assuming the standard local integrability hypotheses on the coefficients $p, q,r$, we study all self-adjoint realizations corresponding to the differential expression in , and, as the principal aim of this paper, systematically construct the associated Donoghue -functions (resp., matrices) in all cases where is in the limit circle case at least at one interval endpoint or .

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