In this paper, we study the Cauchy problem for the energy-critical inhomogeneous nonlinear Schr"{o}dinger equation with inverse-square potential where , , , and . We first prove the local well-posedness as well as small data global well-posedness and scattering in for and , by using the contraction mapping principle based on the Strichartz estimates. Based on the local well-posedness result, we then establish the blowup criteria for solutions to the equation in the focusing case . To this end, we derive the sharp Hardy-Sobolev inequality and virial estimates related to this equation.

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