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This paper concerns the Dirichlet problem of three-dimensional inhomogeneous Navier-Stokes equations with density-dependent viscosity. When the viscosity coefficient is a power function of the density ( with ), it is proved that the system will admit a unique global strong solution as long as the initial data are sufficiently large. This is the first result concerning the existence of large strong solution for the inhomogeneous Navier-Stokes equations in three dimensions.

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