We review recent progress in elucidating the relationship between high-energy radiation and the interstellar medium (ISM) in young supernova remnants (SNRs) with ages of 2000 yr, focusing in particular on RX J1713.73946 and RCW 86. Both SNRs emit strong nonthermal X-rays and TeV -rays, and they contain clumpy distributions of interstellar gas that includes both atomic and molecular hydrogen. We find that shock-cloud interactions provide a viable explanation for the spatial correlation between the X-rays and ISM. In these interactions, the supernova shocks hit the typically pc-scale dense cores, generating a highly turbulent velocity field that amplifies the magnetic field up to 0.1-1 mG. This amplification leads to enhanced nonthermal synchrotron emission around the clumps, whereas the cosmic-ray electrons do not penetrate the clumps. Accordingly, the nonthermal X-rays exhibit a spatial distribution similar to that of the ISM on the pc scale, while they are anticorrelated at sub-pc scales. These results predict that hadronic -rays can be emitted from the dense cores, resulting in a spatial correspondence between the -rays and the ISM. The current pc-scale resolution of -ray observations is too low to resolve this correspondence. Future -ray observations with the Cherenkov Telescope Array will be able to resolve the sub-pc-scale -ray distribution and provide clues to the origin of these cosmic -rays.

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