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Motivated by the recent anomalies observed in semileptonic decays of B-mesons, the class of models denoted as “4321” is introduced and analysed. The importance of calculating next-to-leading-order (NLO) effects in performing precise compatibility tests of data with 4321 predictions is discussed. On the one hand, the coupling of the leptoquark appearing in the spectrum to the third-generation fermions is large, giving rise to sizable NLO corrections in the relevant semileptonic operators. On the other hand, the new source of flavor violation is introduced with the vector-like fermions, resulting in the processes whose relevance can only be quantified at the loop order.

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