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Burden of disease measures the impact of living with illness and injury and dying prematurely and it is increasing worldwide leading cause of death both global and national. This paper aimed to propose an index of diseases and evaluate a mathematical model to describe the number of burden of disease by cause in the Philippines from 1990 - 2016. Through Principal Component Analysis (PCA) the diseases categorized as: passed on diseases, vector born diseases, non-communicable diseases, accident, and intentional. Symbolic Regression Analysis was carried out, the study revealed that the number of burden of disease as categorized using CPA will continue decrease up to year 2020 except on non-communicable disease.

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