We introduce the notion of Hilbert -module independence: Let be a unital -algebra and let $\mathscr{E}_i\subseteq \mathscr{E},,,i=1, 2\mathscr{A}\mathscr{E}\mathscr{E}_1\mathscr{E}_2C^mM$ such that for every state on $\langle \mathscr{E}_i,\mathscr{E}_i\rangle,,,i=1, 2\varphi\mathscr{A}$ such that \begin{align} m\varphi_i(|x|)\leq \varphi(|x|) \leq M\varphi_i(|x|^2)^{\frac{1}{2}},\qquad \mbox{for all~}x\in \mathscr{E}_i, i=1, 2. \end{align*} We show that it is a natural generalization of the notion of -independence of -algebras. Moreover, we demonstrate that even in case of -algebras this concept of independence is new and has a nice characterization in terms of extensions. This enriches the theory of independence of -algebras. We show that if $\langle \mathscr{E}_1,\mathscr{E}_1\rangle z\in \mathscr{E}_1\cap \mathscr{E}_2|z|=1|z|=1$. Several characterizations of Hilbert -module independence and a new characterization of -independence are given. One of characterizations states that if is such that $\langle z_0,z_0\rangle=1\mathscr{E}_1\mathscr{E}_2C^*|\langle x,z_0\rangle\langle y,z_0\rangle|=|\langle x,z_0\rangle|,|\langle y,z_0\rangle|x\in \mathscr{E}_1y\in \mathscr{E}_2$. We also provide some technical examples and counterexamples to illustrate our results.

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