In this paper, we study the orthogonal polynomials with respect to a singularly perturbed Pollaczek-Jacobi type weight By using the ladder operator approach, we establish the second-order difference equations satisfied by the recurrence coefficient and the sub-leading coefficient of the monic orthogonal polynomials, respectively. We show that the logarithmic derivative of can be expressed in terms of a particular Painlev'{e} V transcendent. The large asymptotic expansions of and are obtained by using Dyson’s Coulomb fluid method together with the related difference equations. Furthermore, we study the associated Hankel determinant and show that a quantity , allied to the logarithmic derivative of , can be expressed in terms of the -function of a particular Painlev'{e} V. The second-order differential and difference equations for are also obtained. In the end, we derive the large asymptotics of and from their relations with and .

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