Let be a separable Banach space and let be a linear, bounded, non-negative and symmetric operator and let $A:D(A)\subseteq X\rightarrow X$ be the infinitesimal generator of a strongly continuous semigroup of contractions on . We consider the abstract Wiener space where is a centred non-degenerate Gaussian measure on with covariance operator defined, at least formally, as \begin{align*} Q_\infty=\int_0^{+\infty} e^{sA}Qe^{sA^}ds, \end{align} and is the Cameron–Martin space associated to . Let be the reproducing kernel Hilbert space associated with with inner product . We assume that the operator $Q_\infty A^:D(A^)\subseteq X^\rightarrow XB\in \mathcal L(H)B+B^=-{\rm Id}_H{\rm Id}HHDD^2$ be the first and second order Fr'echet derivative operators, we denote by and the closure in of the operators and and by and and their domains in , respectively,. Furthermore, we denote by the closure of the operator and by its domain in . We characterize the domain of the operator , associated to the bilinear form \begin{align*} (u,v)\mapsto-\int{X}[BD_Hu,D_Hv]Hd\mu\infty, \qquad u,v\in W^{1,2}H(X,\mu\infty), \end{align*} in . More precisely, we prove that coincides, up to an equivalent remorming, with a subspace of . We stress that we are able to treat the case when is degenerate and non-symmetric.

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