In this paper we consider the symmetric Kolmogorov operator $L=\Delta +\frac{\nabla \mu}{\mu}\cdot \nablaL^2(\mathbb R^N,d\mu)\mu$ is the density of a probability measure on . Under general conditions on we prove first weighted Rellich’s inequalities with optimal constants and deduce that the operators and with domain $H^2(\mathbb R^N,d\mu)H^4(\mathbb R^N,d\mu)$ respectively, generate analytic semigroups of contractions on . We observe that is the unique invariant measure for the semigroup generated by and as a consequence we describe the asymptotic behaviour of such semigroup and obtain some local positivity properties. As an application we study the bi-Ornstein-Uhlenbeck operator and its semigroup on .

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