Throughout quantum science and technology, measurement is used as a powerful resource for nonlinear operations and quantum state engineering. In particular, single-photon detection is commonly employed for quantum-information applications and tests of fundamental physics. By contrast, and perhaps counter-intuitively, measurement of the absence of photons also provides useful information, and offers significant potential for a wide range of new experimental directions. Here, we propose and experimentally demonstrate cooling of a mechanical resonator below its laser-cooled mechanical occupation via zero-photon detection on the anti-Stokes scattered optical field and verify this cooling through heterodyne measurements. Our measurements are well captured by a stochastic master equation and the techniques introduced here open new avenues for cooling, quantum thermodynamics, quantum state engineering, and quantum measurement and control.

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