Let , , be the orthogonal polynomials with respect to a given density . Furthermore, let be a density which arises from by multiplication by a rational function in . We prove a formula that expresses the Hankel determinants of moments of in terms of a determinant involving the orthogonal polynomials and associated functions . Uvarov’s formula for the orthogonal polynomials with respect to is a corollary of our theorem. Our result generalises a Hankel determinant formula for the case where the rational function is a polynomial that existed somehow hidden in the folklore of the theory of orthogonal polynomials but has been stated explicitly only relatively recently (see [arXiv:2101.04225]). Our theorem can be interpreted in a two-fold way: analytically or in the sense of formal series. We apply our theorem to derive several curious Hankel determinant evaluations.

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