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In this paper we establish the optimal regularity estimates for the Cauchy problem of stochastic kinetic equations with random coefficients in anisotropic Besov spaces. As applications, we study the nonlinear filtering problem for a degenerate diffusion process, and obtain the existence and regularity of conditional probability densities under few assumptions. Moreover, we also show the well-posedness for a class of super-linear growth stochastic kinetic equations driven by velocity-time white noises, as well as a kinetic version of Parabolic Anderson Model with measure as initial values.

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