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We consider the non-relativistic quantum Boltzmann equation for fermions and bosons. Using the nonlinear energy method and mild formulation, we justify the global well-posedness when the density function is near the global Maxwellian and vacuum. This work is a generalization and adaptation of the classical Boltzmann theory. Our main contribution is a detailed analysis of the nonlinear operator in the quantum context. This is the first piece of a long-term project on the quantum kinetic equations.

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