The full sky measurements of the Cosmic Microwave Background (CMB) temperature anisotropies by and have highlighted the presence of several unexpected isotropy-breaking features on the largest angular scales. In this work, we investigate the impact of the local large-scale structure on these anomalies through the thermal and kinetic Sunyaev-Zeldovich effects. We use a constrained hydrodynamical simulation that reproduces the local Universe in a box of Mpc to construct full sky maps of the temperature anisotropies produced by these two CMB secondary effects and discuss their statistical properties on large angular scales. We show the significant role played by the Virgo cluster on these scales, and compare it to theoretical predictions and random patches of the universe obtained from the hydrodynamical simulation . We explore three of the main CMB large-scale anomalies – i.e., lack of correlation, quadrupole-octopole alignment and hemispherical asymmetry – , both in the latest data (PR4), where they are detected at a similar level to the previous releases, and using the simulated secondaries from the local Universe, verifying their negligible impact.

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