After a review over past experiments and theoretical requirements from low-energy flavour physics, we argue that the possibility of low-mass leptoquarks (LQ) cannot be fully excluded due to the assumptions made in the measurements. Therefore we propose to search for the pair production of low-mass leptoquarks in Pb-Pb ultra-peripheral collisions with the least model dependence (assuming a small coupling constant ). There are a couple of advantages: 1) high photon flux provides high production rate for low mass LQs; 2) the background contamination is much lower than that in - collisions. The analysis strategy permits a leptoquark to decay to all possible lepton-plus-quark modes. Taking the scalar LQ, , with an electric charge , as example, the mass point of 100 GeV can be excluded at the 95~% confidence level using a dataset of 4~pb Pb-Pb ultra-peripheral collisions at TeV and the performance of the ATLAS detector in Run~2. The proposed method also applies to searching for high-mass LQs in - collisions as long as the LQ pair production mechanism dominates.

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