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Given a closed four-manifold with an indefinite intersection form, we consider smoothly embedded surfaces in int, with boundary a knot . We give several methods to bound the genus of such surfaces in a fixed homology class. Our tools include adjunction inequalities and the theorem. In particular, we present obstructions to a knot being H-slice (that is, bounding a null-homologous disk) in a four-manifold and show that the set of H-slice knots can detect exotic smooth structures on closed -manifolds.

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