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In this work, we consider effects of the dynamical vacuum in quantum cosmology in presence of a minimum length introduced by the GUP (generalized uncertainty principle) related to the modified commutation relation . We determine the wave function of the Universe , which is solution of the modified Wheeler-DeWitt equation in the representation of the quasi-position space, in the limit where the scale factor of the Universe is small. Although is a physically acceptable state it is not a realizable state of the Universe because has infinite norm, as in the ordinary case with no minimal length.

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