We present results from a new cosmological hydrodynamics simulation campaign of protocluster (PC) regions, FOREVER22: FORmation and EVolution of galaxies in Extremely-overdense Regions motivated by SSA22. The simulations cover a wide range of cosmological scales using three different zoom set-ups in a parent volume of : PCR (Proto-Cluster Region; $V= (28.6~{\rm cMpc})^{3} m_{\rm{SPH}} = 4.1 \times 10^{6}~\rm M_{\odot}z_{\rm end}=2.0$), BCG (Brightest proto-Cluster Galaxy; , $m_{\rm SPH} = 5.0\times10^{5}~\rm M_{\odot}z_{\rm end}=4.0V \sim (3~{\rm cMpc})^{3} m_{\rm SPH} = 7.9 \times 10^{3}~\rm M_{\odot}z_{\rm end}=9.5$) runs, that allow to focus on different aspects of galaxy formation. In the PCR runs, we follow 10 PCs, each harbouring 1 - 4 SMBHs with $M_{\rm BH} \ge 10^{9}~\rm M_{\odot}$. One of the PC cores shows a spatially close arrangement of seven starburst galaxies with each, that are dust-obscured and would appear as submillimeter galaxies with flux mJy at in observations. The BCG runs show that the total SFRs of haloes hosting BCGs are affected by AGN feedback, but exceed at . The First runs resolve mini-haloes hosting population (Pop) III stars and we show that, in PC regions, the dominant stellar population changes from Pop III to Pop II at $z \gtrsim 20{\rm SFR} \gtrsim 18~\rm M_{\odot}~yr^{-1}z \sim 10$. These can be prime targets for future observations with the James Webb Space Telescope. Our simulations successfully reproduce the global star formation activities in observed PCs and suggest that PCs can kickstart cosmic reionization.

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