Spectral distortions of the cosmic microwave background (CMB) are sensitive to energy injection by exotic physics in the early universe. The proposed Primordial Inflation Explorer (PIXIE) mission has the raw sensitivity to provide meaningful limits on new physics, but only if foreground emission can be adequately modeled. We quantify the impact of interstellar dust on Compton and measurements by considering a range of grain size distributions and compositions constrained by theoretical and observational priors (Zelko & Finkbeiner 2020). We find that PIXIE can marginalize over a modest number of dust parameters and still recover and estimates, though with increased uncertainty. As more foreground components are included (synchrotron, free-free), the estimates of degrade, and measurement of in the range sometimes considered for the standard CDM of becomes infeasible without ancillary low-frequency foreground information. An additional concern is dust absorption of the CMB monopole, a subtle effect that must be included. We quantify one form of model discrepancy error, finding that the error introduced by fitting our interstellar medium dust model with a modified blackbody is too large for CMB spectral distortions to be detectable. The greatest challenge may be the cosmic infrared background (CIB). We find that and are extremely sensitive to modeling choices for the CIB, and quantify biases expected for a range of assumptions.

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