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We study in this paper the small data Cauchy problem for the semilinear generalized Tricomi equations with a nonlinear term of derivative type for . Blow-up result and lifespan estimate from above are established for . If , our results coincide with those of the semilinear wave equation. The novelty consists in the construction of a new test function, by combining cut-off functions, the modified Bessel function and a harmonic function. Interestingly, if the blow-up power is independent of . We also furnish a local existence result, which implies the optimality of lifespan estimate at least in the -dimensional case.

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