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We study finite time blow-up and global existence of solutions to the Cauchy problem for the porous medium equation with a variable density and a power-like reaction term. We show that for small enough initial data, if as $|x|\to \inftyp>1\rho(x)\sim\frac{\left(\log|x|\right)^{\alpha}}{|x|^{2}}|x|\to \infty$, if the initial datum is small enough then one has global existence of the solution for any , while if the initial datum is large enough then the blow-up of the solutions occurs for any . Such results generalize those established in [27] and [28], where it is supposed that for as .

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