In this paper we consider domino tilings of bounded regions in dimension $n \geq 4{}/(2)$, and prove it is invariant under flips, a simple local move in the space of tilings. We investigate which regions are regular, i.e. whenever two tilings and of have the same twist then and can be joined by a sequence of flips provided some extra vertical space is allowed. We prove that all boxes are regular except . Furthermore, given a regular region , we show that there exists a value (depending only on ) such that if and are tilings of equal twist of then the corresponding tilings can be joined by a finite sequence of flips in . As a corollary we deduce that, for regular and large , the set of tilings of has two twin giant components under flips, one for each value of the twist.

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