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We calculate the two-loop beta functions of the right-handed neutrino mass matrix in the Standard Model extended with right-handed neutrinos. We show that two-loop quantum effects induced by the heavier right-handed neutrinos can induce sizable contributions (sometimes dominant) to the physical masses of the lighter right-handed neutrinos. These effects can significantly affect the masses of the active neutrinos in the seesaw mechanism and the low energy phenomenology.

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